Active Genetics and CRISPR

Active Genetics is the non-Mendelian transmission of heritable traits by means of self-propagating genetic elements. Based on The CRISPR technology, it was conceived and developed in pioneering work on Drosophila melanogaster (Gantz and Bier, 2015; Science, April 24, 2015: Genome editing. The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations). This new technology has great potential for the biological control of insect vectors of disease, invasive animal species and to correct human genes linked to disease.

Lima L, Berni M, Mota J, Bressan D, Julio A, Cavalcante R, Macias V, Li Z, Rasgon JL, Bier E, Araujo H. Gene Editing in the Chagas Disease Vector Rhodnius prolixus by Cas9-Mediated ReMOT Control. CRISPR J. 2024 Apr;7(2):88-99. doi: 10.1089/crispr.2023.0076. Epub 2024 Apr 1. PMID: 38564197.

Bressan D, Araujo H, Ciência Hoje, Out 2016. Edição de genomas: Arma no controle de insetos transmissores de doenças.